ToolKit eVITAL

Evaluación de los estilos de vida y hábitos saludables para el envejecimiento activo.


REVERASTROL. Activating neuroprotective pathways

REVERASTROL. Activating neuroprotective pathways

Latent herpes simplex virus type-1 (HSV-1) DNA has been found in the brains of post-mortem infected individuals with infection estimated at up to 70% of the population over 50 years old. There is evidence that recurrent asymptomatic reactivations can lead to early neurodegenerative events supported by higher titers of HSV-1 antibodies associated with atrophic cortical gray matter volume and cognitive impairments in Alzheimer’s patients.

Leyton et al. (2015) evaluated known natural activators of the AMPK/Sirt 1 sensors involved in neuronal survival pathways and neuroprotection, including Resveratrol and Quercetin, to determine if activation could reduce HSV-1 propagation or counteract the effects of CNS neuronal infection. The Quick-DNA™ Universal Kit was utilized for isolation of DNA from HT22 neuronal cells for infectivity studies. Results of the study suggested that activators of the AMPK/Sirt 1 axis increased the viability of infected neurons, reduced viral titer in the supernatant, and reduced the expression of viral genes. Pretreatment with Resveratrol and Quercetin reduced the cleaving and hyperphosphorylation of tau that is normally associated with HSV-1 infection. This indicates that Resveratrol and Quercetin could be useful in reducing the risk of HSV-1 infection in neurons and the cellular damage caused by reactivation events that have been associated with early neurodegeneration, such as in Alzheimer’s disease.

Fecha: 14/09/2015